Mitsuru Shinohara Selected Research

Apolipoprotein E2

11/2020	APOE2: protective mechanism and therapeutic implications for Alzheimer's disease.
10/2020	APOE2 is associated with longevity independent of Alzheimer's disease.
1/2020	Interaction between APOE genotype and diabetes in cognitive decline.
5/2016	APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations.
4/2014	Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway.

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Mitsuru Shinohara Research Topics

Disease

33	Alzheimer Disease (Alzheimer's Disease) 11/2021 - 04/2007
8	Cognitive Dysfunction 01/2020 - 05/2008
4	Prostatic Neoplasms (Prostate Cancer) 01/2021 - 05/2003
4	Dementia (Dementias) 01/2020 - 05/2008
2	Disease Progression 01/2020 - 08/2009
2	Neuroinflammatory Diseases 10/2018 - 01/2017
2	Neoplasm Metastasis (Metastasis) 01/2017 - 05/2011
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2017 - 11/2015
2	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 01/2017 - 01/2016
2	Amyloid Plaque 12/2013 - 11/2012
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 11/2020
1	Nervous System Diseases (Neurological Disorders) 11/2020
1	Dyslipidemias (Dyslipidemia) 01/2019
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 10/2018
1	Corticobasal Degeneration 10/2018
1	Tauopathies 10/2018
1	Frailty 09/2017
1	Amyloidosis 01/2017
1	Carcinoma (Carcinomatosis) 01/2017
1	Weight Loss (Weight Reduction) 03/2016
1	Hepatomegaly 03/2016
1	Liver Failure 03/2016
1	Xeroderma Pigmentosum (Kaposi's Disease) 01/2016
1	Frontotemporal Dementia (Semantic Dementia) 01/2016
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2016
1	Gliosis 05/2015
1	Atrophy 01/2014
1	Hypertension (High Blood Pressure) 01/2014
1	Hypercholesterolemia 01/2014
1	Spinal Cord Compression 09/2013
1	Paralysis (Palsy) 09/2013
1	Eosinophilia 01/2013
1	Pathologic Complete Response 07/2012
1	Muscular Diseases (Myopathy) 07/2012
1	Testicular Neoplasms (Testicular Cancer) 07/2012
1	Polymyositis 07/2012
1	Aspiration Pneumonia 07/2012
1	Memory Disorders (Memory Loss) 04/2010
1	Neoplasms (Cancer) 01/2006

Drug/Important Bio-Agent (IBA)

16	Amyloid (Amyloid Fibrils)IBA 10/2020 - 11/2012
13	Apolipoproteins E (ApoE)IBA 01/2021 - 04/2013
13	ApolipoproteinsIBA 01/2021 - 04/2013
9	Peptides (Polypeptides)IBA 01/2019 - 04/2007
7	Proteins (Proteins, Gene)FDA Link 01/2019 - 05/2014
6	Apolipoprotein E4IBA 01/2020 - 04/2014
5	Apolipoprotein E2IBA 11/2020 - 04/2014
5	Amyloid beta-PeptidesIBA 01/2012 - 05/2008
4	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2014 - 05/2008
3	Apolipoprotein E3IBA 01/2020 - 04/2014
2	EnzymesIBA 11/2021 - 12/2017
2	ImmunosorbentsIBA 11/2021 - 12/2017
2	AndrogensIBA 01/2021 - 01/2020
2	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 09/2017
2	Presenilin-1IBA 01/2017 - 05/2014
2	Alkaline PhosphataseIBA 01/2017 - 05/2011
2	Protein Isoforms (Isoforms)IBA 01/2017 - 05/2015
2	C-Reactive ProteinIBA 01/2017 - 05/2011
2	Pharmaceutical PreparationsIBA 01/2017 - 07/2009
2	Biomarkers (Surrogate Marker)IBA 01/2017 - 07/2009
2	CholesterolIBA 05/2016 - 01/2014
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 02/2015 - 04/2007
1	LipidsIBA 01/2019
1	OccludinIBA 01/2019
1	Claudin-5IBA 01/2019
1	Tight Junction ProteinsIBA 01/2019
1	SynaptophysinIBA 01/2019
1	LDL Receptors (LDL Receptor)IBA 01/2017
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2017
1	Hemoglobins (Hemoglobin)IBA 01/2017
1	AlbuminsIBA 01/2017
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 03/2016
1	Bexarotene (LGD1069)FDA Link 03/2016
1	poly(glycyl-alanyl)IBA 01/2016
1	Ubiquitinated ProteinsIBA 01/2016
1	tau Proteins (tau Protein)IBA 11/2015
1	Immunoglobulin G (IgG)IBA 01/2013
1	Immunoglobulin E (IgE)IBA 01/2013
1	Antinuclear AntibodiesIBA 01/2013
1	Tumor Biomarkers (Tumor Markers)IBA 07/2012
1	Creatine Kinase (Creatine Phosphokinase)IBA 07/2012
1	Antihypertensive Agents (Antihypertensives)IBA 12/2009
1	olmesartanIBA 12/2009
1	Angiotensin Receptor AntagonistsIBA 12/2009
1	CA-19-9 Antigen (CA 19-9 Antigen)IBA 08/2009
1	CarbohydratesIBA 08/2009
1	Galantamine (Galanthamine)FDA LinkGeneric 07/2009
1	Amyloid beta-Protein Precursor (Amyloid Protein Precursor)IBA 04/2007
1	Aspartic Acid ProteasesIBA 04/2007
1	Hormones (Hormone)IBA 05/2003

Therapy/Procedure

5	Therapeutics 01/2021 - 05/2003
4	Radiotherapy 01/2021 - 05/2003
2	Drug Therapy (Chemotherapy) 01/2017 - 07/2012
1	Castration 01/2020
1	Cystectomy 01/2017
1	Conservative Treatment 09/2013
1	Mechanical Ventilators (Ventilator) 07/2012
1	Oral Administration 12/2009
1	Adrenalectomy 01/2006